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Crabtree in for inactive 49ers WR Bruce (AP) (sports.yahoo.com)

San Francisco 49ers wide receiver Isaac Bruce is inactive against the Chicago Bears with an ankle injury. Bruce is being replaced in the starting lineup Thursday night by rookie Michael Crabtree. Other players inactive for San Francisco are defensive backs Nate Clements and Keith Smith; running back Glen Coffee; offensive linemen Cody Wallace and Joe Staley; and defensive lineman Demetric Evans.

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